ABSTRACT

Lung cryptococcosis is a rare entity whose epidemiology hasn't been entirely reported in Mexico. It is frequently found as a complication of HIV or other cases of immunosuppression. We present a case of a young immunocompetent man who debuted with neurological manifestations and was later found to have a giant lung cryptococcoma. This is a particularly interesting case because although the clinical manifestations were normal, the patient was not immunocompromised and the lung damage was important with later development of meningitis that led to complications and a lung resection.

KEYWORDS

cryptococcoma, giant, lung, immunocompetent.

REFERENCES

1. Carrada BT. Criptococosis en la era del sida. Rev Mex Patol Clin Med Lab. 2003;50(1):33-40.

2. Haddad N, Cavallaro MC, Lopes MP, Fernandez JM, Laborda LS, Otoch JP, et al. Pulmonary cryptococcoma: a rare and challenging diagnosis in immunocompetent patients. Autops Case Rep. 2015;5(2):35-40.

3. Hsiao PJ, Cheng H, Kao YH, Wang YH, Chiu CC, Chiang WF, et al. Comparison of laboratory diagnosis, clinical manifestation, and management of pulmonary cryptococcosis: Report of the clinical scenario and literature review. Clin Chim Acta. 2022;524:78-83.

4. French N, Gray K, Watera C, Nakiyingi J, Lugada E, Moore M, et al. Cryptococcal infection in a cohort of HIV-1-infected Ugandan adults. AIDS. 2002;16(7):1031-1038.

5. Menon A, Rajamani R. Giant 'cryptococcoma' of the lung. Br J Dis Chest. 1976;70(4):269-272.

6. Abassi M, Boulware DR, Rhein J. Cryptococcal meningitis: diagnosis and management update. Curr Trop Med Rep. 2015;2(2):90-99.

7. Zhang B, Wang L, Qian B, Liu W, Shi H. Standard antifungal therapy for pulmonary cryptococcosis to improve prognosis. Lancet Infect Dis. 2019;19(12):1281.

8. Saag MS, Graybill RJ, Larsen RA, Pappas PG, Perfect JR, Powderly WG, et al. Practice guidelines for the management of cryptococcal disease. Clin Infect Dis. 2000;30(4):710-718.

9. Nadrous HF, Antonios VS, Terrell CL, Ryu JH. Pulmonary cryptococcosis in nonimmunocompromised patients. Chest. 2003;124(6):2143-2147.