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The economic burden of COPD. Cost analysis at international level

David Martínez Briseño, Ma del Rosario Fernández Plata, Ma Cecilia García Sancho Figueroa, Rogelio Pérez Padilla





2011, Number 2

2011; 70 (2)






ABSTRACT

Background and objective: Chronic obstructive pulmonary disease (COPD) is a major cause of chronic morbidity and mortality worldwide. Studies on the economic burden of COPD have been conducted mainly in Europe and North America. For Latin America there are few studies. The aim of this study was to conduct a literature review of the economic burden of COPD worldwide.
Material and methods: Studies were identified through systematic literature review using electronic databases in PubMed between 2000-2010. We included studies which carried out microeconomic analysis of COPD.
Results: We included 32 studies in the literature review. In twenty six were used the patient costs in order to estimate the economic burden of COPD. For patients the range of mean direct cost (USD) was (70.69-44,016.72), for exacerbation was (15.35-11,729). The ranges of mean indirect cost were (60.34-7,365.00) and (20.05-123.70) for patient and exacerbation, respectively. The proportion of direct costs was between 32.96 and 97.74%. The main items related to the direct costs were hospitalization and drugs.
Conclusion: There is a wide variety in direct and indirect cost of COPD among countries. It is necessary to develop studies about economic burden of COPD in Mexico in order to evaluate programs which prevent the disease and minimize the cost of Health care.

KEYWORDS

COPD, economic burden, inpatient care, literature review.

REFERENCES

  1. Murray CJ, Lopez AD. Alternative projections of mortality and disability by cause 1990-2020: Global Burden of Disease Study. Lancet 1997;349:1498-1504.

  2. Lopez AD, Mathers CD. Measuring the global burden of disease and epidemiological transitions: 2002-2030. Ann Trop Med Parasitol 2006;100:481-499.

  3. World Health Organization. Fact sheet N°315, November 2007, Chronic obstructive pulmonary disease (COPD). Access date: 09/IV/2008. Available from: http://www.who.int/mediacentre/factsheets/fs315/en/index.html.

  4. Tan WC, Ng TP. COPD in Asia: where East meets West. Chest 2008;133:517-527.

  5. European Respiratory Society/European Lung Foundation. Chronic Obstructive Pulmonary Disease. In: European Lung Foundation. European Lung White Book. Laussane: European Respiratory Society; 2003.p.34-43.

  6. Halbert RJ, Isonaka S, Georg D, Iqbal A. Interpreting COPD prevalence estimates: what is the true burden of disease? Chest 2003;123:1684-1692.

  7. Minkoff NB. Analysis of the current care model of the COPD patient: a health outcomes assessment and economic evaluation. J Manag Care Pharm 2005;11(6 Suppl A):3-7.

  8. Dal Negro R, Berto P, Tognella S, Quareni L; Global Outcomes in Lung Disease Study Group. Cost-of-illness of lung disease in the TriVeneto Region, Italy: the GOLD Study. Monaldi Arch Chest Dis 2002;57:3-9.

  9. Rennard S, Decramer M, Calverley PMA, et ál. Impact of COPD in North America and Europe in 2000: subjects’ perspective of Confronting COPD International Survey. Eur Respir J 2002;20:799-805.

  10. Chapman KR, Mannino DM, Soriano JB, et ál. Epidemiology and costs of chronic obstructive pulmonary disease. Eur Respir J 2006;27:188-207.

  11. Secretaría de Salud. Sistema Nacional de Información en Salud. Mortalidad. Principales causas de mortalidad general 2000-2005. Fecha de acceso: 09/VII/2008. Disponible en: http://sinais.salud.gob.mx/interior/mortalidad/

  12. Menezes AM, Perez-Padilla R, Jardim JR, et ál. Chronic obstructive pulmonary disease in five Latin American cities (the PLATINO study): a prevalence study. Lancet 2005;366:1875-1881.

  13. Reynales-Shigematsu LM, Juárez-Márquez SA, Valdés-Salgado R. Costos en atención médica atribuibles al tabaquismo en el IMSS, Morelos. Salud Pública Méx 2005;47:451-457.

  14. Chiang CH. Cost analysis of chronic obstructive pulmonary disease in a tertiary care setting in Taiwan. Respirology 2008;13:689-694.

  15. Mittmann N, Kuramoto L, Seung SJ, Hadon JM, Bradley-Kennedy C, Filzgerald JM. The cost of moderate and severe COPD exacerbations to the Canadian healthcare system. Respir Med 2008;102:413-421.

  16. Zhang B, Zhang Y, Yang J, Liu X. Analysis on direct economic burden of community COPD patients and its influence factors in Chengdu. Wei Sheng Yan Jiu 2007;36:706-710.

  17. Ramírez VA. Panorama epidemiológico e impacto económico actual. Neumol Cir Torax 2007;66(sup 2):13-16.

  18. United States Department of Labor. Bureau of Labor Statistics. Consumer Price Index 2011. Access date: 18/IV/2011. Available from: ftp://ftp.bls.gov/pub/special.requests/cpi/cpiai.txt

  19. Jansson SA, Andersson F, Borg S, Ericsson A, Jönsson E, Lundbäck B. Costs of COPD in Sweden according to disease severity. Chest 2002;122: 1994-2002.

  20. Andersson F, Borg S, Jansson SA, et ál. The costs of exacerbations in chronic obstructive pulmonary disease (COPD). Respir Med 2002;96:700-708.

  21. Miravitlles M, Murio C, Guerrero T, Gisbert R; DAFNE Study Group. Pharmacoeconomic evaluation of acute exacerbations of chronic bronchitis and COPD. Chest 2002;121;1449-1455.

  22. Miravitlles M, Murio C, Guerrero T, Gisbert R. Costs of chronic bronchitis and COPD: a 1-year follow-up study. Chest 2003;123;784-791.

  23. Halpern MT, Stanford RH, Borker R. The burden of COPD in the U.S.A.: results from the Confronting COPD survey. Respir Med 2003;97 Suppl C:81-89.

  24. Chapman KR, Bourbeau J, Rance L. The burden of COPD in Canada: results from the Confronting COPD survey. Respir Med 2003;97 Suppl C:23-31.

  25. Piperno D, Huchon G, Pribil C, Boucot I, Similowski T. The burden of COPD in France: results from the Confronting COPD survey. Respir Med 2003;97 Suppl C:33-42.

  26. Dal Negro R, Rossi A, Cervei I. The burden of COPD in Italy: results from the Confronting COPD survey. Respir Med 2003;97 Suppl C:43-50.

  27. Izquierdo JL. The burden of COPD in Spain: results from the Confronting COPD survey. Respir Med 2003;97 Suppl C:61-69.

  28. Britton M. The burden of COPD in the U.K.: results from the Confronting COPD su.rvey. Respir Med 2003;97 Suppl C:71-79.

  29. Wouters EF. The burden of COPD in the Netherlands: results from the Confronting COPD survey. Respir Med 2003;97 Suppl C:51-59.

  30. Masa JF, Sobradillo V, Villasante C, et ál. Costes de la EPOC en España. Estimación a partir de un estudio epiemiológico poblacional. Arch Bronconeumol 2004;40:72-79.

  31. Strâmbu I, Bucşa S, Nicolescu D, Dumitrescu C, Grigorescu B, Stoicescu IP. Cost analysis in patients admitted with COPD in 2002. Pneumologia 2004;53:161-168.

  32. Jahnz-Rózyk K, Targowski T, From S, Płusa T. Retrospective analysis of direct costs of hospital treatment of chronic obstructive pulmonary disease exacerbations. Pol Merkur Lekarski 2004;16 Suppl 1:91-94.

  33. Miller JD, Foster T, Boulanger L, et ál. Direct costs of COPD in the U.S.: an analysis of Medical Expenditure Panel Survey (MEPS) data. COPD 2005;2:311-318.

  34. Reynales-Shigematsu LM, Rodríguez-Bolaños RA, Jiménez JA, Juárez-Márquez SA, Castro-Ríos A, Hernández-Ávila M. Costos de la atención médica atribuibles al consumo de tabaco en el Instituto Mexicano del Seguro Social. Salud Pública Méx 2006;48(sup 1):48-64.

  35. Nurmagambetov T, Atherly A, Williams S, Holguin F, Mannino DM, Redd SC. What is the cost to employers of direct medical care for chronic obstructive pulmonary disease? COPD 2006;3:203-209.

  36. Pérez AN, Murillo MR, Pinzón FC, Hernández G. Costos de la atención médica del cáncer de pulmón, la EPOC y el IAM atribuibles al consumo de tabaco en Colombia (proyecto multicéntrico de la OPS). Rev Col Cancerol 2007;11:241-249.

  37. 37 Jahnz-Rózyk K, Targowski T, From S. Comparison of outpatient and inpatient costs of moderate and severe exacerbations of chronic obstructive pulmonary disease in Poland. Pneumonol Alergol Pol 2008;76:426-431.

  38. Menzin J, Boulanger L, Marton J, et ál. The economic burden of chronic obstructive pulmonary disease (COPD) in a U.S. Medicare population. Respir Med 2008;102:1248-1256.

  39. Jahnz-Rózyk K, Targowski T, From S. Cost of exacerbation of chronic obstructive pulmonary disease in primary and secondary care in 2007- results of multicenter Polish study. Pol Merkur Lekarski 2009;26:208-214.

  40. Simoni-Wastila L, Blanchette CM, Qian J, et ál. Burden of chronic obstructive pulmonary disease in Medicare beneficiaries residing in long-term care facilities. Am J Geriatr Pharmacother 2009;7:262-270.

  41. Bakerly ND, Davies C, Dyer M, Dhillon P. Cost analysis of an integrated care model in the management of acute exacerbations of chronic obstructive pulmonary disease. Chron Respir Dis 2009;6:201-208.

  42. Zhu ML, Cai BQ. Costs of the last hospitalization for patients with acute exacerbation of chronic obstructive pulmonary disease and patients with lung cancer. Zhonghua Jie He He Hu Xi Za Zhi 2009;32:258-261.

  43. He QY, Zhou X, Xie CM, Liang ZA, Chen P, Wu CG. Impact of chronic obstructive pulmonary disease on quality of life and economic burden in Chinese urban areas. Zhonghua Jie He He Hu Xi Za Zhi 2009;32:253-257.

  44. Sharafkhaneh A, Petersen NJ, Yu HJ, Dalal AA, Johnson ML, Hanania NA. Burden of COPD in a government health care system: a retrospective observational study using data from the US Veterans Affairs population. Int J Chron Obstruct Pulmon Dis 2010;5:125-132.

  45. Dalal AA, Shah M, D’Souza AO, Rane P. Costs of inpatient and emergency department care for chronic obstructive pulmonary disease in an elderly Medicare population. J Med Econ 2010;13:591-598.

  46. Dalal AA, Christensen L, Liu F, Riedel AA. Direct costs of chronic obstructive pulmonary disease among managed care patients. Int J Chron Obstruct Pulmon Dis 2010;5:341-349.

  47. Wouters EF. Economic analysis of the Confronting COPD survey: an overview of results. Respir Med 2003;97 Suppl C:S3-S14.


2011, Number 2

2011; 70 (2)